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Hypericum & Depression
Study 19
Nocturnal melatonin and cortisol secretions before and after subchronic administration of Hyperforat.
AU:Demisch-L, Nispel-J, Sielaff-T, Gebhart-P, Köhler-C, Pflug-B
SO:Abstract from the AGNP-symposium, Nuernberg 1991.
Description
Nocturnal plasma profiles were measured in 12 healthy volunteers before and after 3 weeks of hypericum treatment (Hyperforat, 90 drops/day). They also received light treatment with either 300 or > 2500 lux before and after hypericum treatment. Plasma melatonin and cortisol were measured by immunometric methods.
Results
- Before medication only pulses of 2,500 lux, but not pulses of 300 lux , suppressed melatonin plasma levels.
- After medication light pulses of 300 lux also had a significant effect
- The nocturnal secretion of melatonin increased significantly after medication.
- After three weeks of medication, nocturnal stress stimulation (awakening and sitting) led to a significantly smaller increase in plasma cortisol.
Researchers' conclusion
- Subchronic intake of hypericum changed mechanisms of the visual system associated with the production of melatonin. "Stress" induced nocturnal cortisol secretions may also contribute to a therapeutic effect.
Copyright © 1996 by Harold H. Bloomfield, M.D. and Peter McWilliams
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